Blandine de Sansal began her musical training by joining the Maîtrise de la Légion d'Honneur as a child. In 2010, she enters the École Normale Alfred Cortot in the class of Mireille Alcantara, while completing this training with a Bachelor of Musicology at the Sorbonne. She distinguished herself in various competitions, notably at the Concours International de Musique et d’Art Dramatique Léopold Bellan, where she won a First Prize in 2015, then at the Lied et Mélodie competition of the Saisons de la Voix where she was awarded the Prix de la Ville de Gordes in 2016. In April 2017 she was awarded the Diplôme Supérieur de Concertiste of the Ecole Normale de Musique de Paris. She won the 1st prize of the International Baroque Singing Competition of Froville in 2022, as well as the Public Prize.

She sings as a soloist under the direction of Sébastien Daucé (Ensemble Correspondances), Damien Guillon (Le Banquet Céleste), Jérôme Corréas (Les Paladins), Stéphane Fuget (Les Epopées), Paul Agnew (Les Arts Florissants) and Jean-Christophe Spinosi (Ensemble Matheus). She also sings with talented ensembles such as the Ensemble Pygmalion (Raphaël Pichon), the Ensemble Marguerite Louise (Gaétan Jarry) and the Ensemble Zene (Bruno Kele-Baujard).

On stage, she plays Barberine in Les Noces de Figaro (Mozart), Fragoletto in Les Brigands (Offenbach), Lisbé (Zémire et Azor by Grétry directed by Mireille Larroche) under the direction of Jérôme Corréas. She sings as a solo viola in Rossini's La Petite Messe Solennelle in a version directed by Jos Houben and Emily Wilson, a show created in December 2019 at the Opéra de Rennes. She then takes the role of Argene in Antonio Vivaldi's L'Olimpiade under the direction of Jean-Christophe Spinosi, in a concert version. She also took part as a soloist in the recent stage creation of the Ensemble Correspondances at the Aix-en-Provence Festival: Combattimento, La Théorie du Cygne Noir, directed by Silvia Costa in July 2021. She then sang the role of Goffredo at the Opéra de Rennes in Handel's Rinaldo under the direction of Damien Guillon (directed by Claire Dancoisne), then at the Opéra d'Avignon under the direction of Bertrand Cuiller in the same production.